Posts Tagged uricosuric
Is Febuxostat (Uloric®) Really Better Than Allopurinol?
Posted by Victor Konshin in Gout Treatments on July 3, 2009
UK’s National Institute of Health and Clinical Excellence doesn’t think so. In December it issued guidance that the benefits febuxostat (sold in the US under the brand name Uloric®) have not been clearly demonstrated.
The argument is that the pharmaceutical companies tested febuxostat against a fixed dose of 300mg of allopurinol per day. Even though this is the way most doctors prescribe allopurinol, it is not the best way to use it according the expert “best practices” guidelines. The appropriate way is to adjust the dose of allopurinol until uric acid levels are lowered to below 6mg/dL (333µm/L). Allopurinol can safely be prescribed up to 900mg/day.
Because the pharmaceutical companies did not show that febuxostat was more effective than allopurinol when allopurinol is used this way, and because of the cost and other risks, they concluded that for most people it best to just stick with allopurinol.
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Uric Acid Levels and Gout
Posted by Victor Konshin in Diet, General, Gout Treatments on May 8, 2009
If you have gout, it is important to get your uric acid levels tested regularly. This is important for a couple of reasons. First, if you are taking medication, or even natural remedies to lower uric acid levels, you want to make sure that they are actually working. You also want to make sure that you are maintaining a healthy uric acid level – too much uric acid and gout can occur (bad) – too little uric acid and neurological issues can occur (rare, but worse).
Second, uric acid levels can fluctuate wildly, from day to day, even hour to hour. A blood test gives you a snapshot of what your uric acid level is at that moment. You could be having a good day and your uric acid level is low. This might make you feel as though you do not need to take so much medication and scale back. Unfortunately, this will likely result in a gout attack.
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Swine Flu and Gout
Posted by Victor Konshin in General, Gout Treatments on April 28, 2009
I have been sitting in my office this morning with the television on, watching the coverage of the swine flu outbreak. I am always impress at how much panic an infections disease can generate. Personally, if the swine flu does become pandemic, I hope I am one of the first to come down with the disease. Why? With a disease as virulent as the flu, the odds are very good that I will develop the disease eventually and if that happens, I want to get it before the medical system is overloaded and drugs like Tamiflu run out. Beside, I am a healthy 38 year old and the risk of serious complications, let alone death, are small. This way, I would get the best care, medications, will get it over with quickly, and be healthy (and immune to the disease) when the disease hits it’s peak so I can help care for others. So you won’t find me walking around with a mask on – which really doesn’t provide much protection anyway.
What does swine flu have to do with gout?
Not much really, however some medications used to treat gout can suppress the immune system which can make you more susceptible to disease including the flu and can make the flu worse if you should get it. If you are unlucky enough to develop the flu just as you are being treated with corticosteroids or colchicine for a gout attack, it could make it much worse - particularly if you are elderly. Note that NSAIDs and medications to lower uric acid levels do not suppress the immune system.
Of course, if you manage gout properly by lowering uric acid levels, there is no need to ever treat a gout attack because you will not get them.
Update: NYC Assistant Principal in Critical Condition
In New York City an Assistant Principal has come down with the N1H1 flu and is now in critical condition. It has been reported in the media that the only preexisting health condition he had was gout. As a result I have seen a lot of interest in any possible connection between gout and swine flu. It has been reported in the media that this Assistant Principal is suffering from kidney failure. As I have written previously (see,Is Gout Dangerous) that gout is strongly associated with kidney failure. If fact, nearly all people suffering from gout have significant kidney damage at the time of death.
So, did gout combine with swine flu contribute to this man’s kidney failure? That remains to be seen, but I would not be surprised if this turns out to be the case. The flu could have found a comfortable home in the already damaged kidneys. As the disease spreads, we will see if more people suffering from gout develop serious kidney complications.
Update 2: NYC Assistant Principal Passes Away
Unfortunately, NYC Assistant Principal Matthew Wiener passed away Sunday, May 17th. Our sympathies go out to his family.
As for the connection between gout and swine flu… Its unlikely that gout played a role, but it is possible. I hope that the CDC takes a close look to see if there was a connection. If they can find a connection, then I hope that they will at least advise the public of the risk and advise the medical community to treat those that have gout and develop swine flu more aggressively.
Kidney Stones, a Gout Early Warning?
Posted by Victor Konshin in General, New Research on April 22, 2009
The “German Professional Association of Internists” released a statement on Monday saying that kidney stones may be an early warning sign for gout. The statement claimed that as many as 40% developed kidney stones as a first indication of gout.
This makes sense. It had been known for a long time that high levels of uric acid in the body can cause increased levels of uric acid excreted by the kidneys. This excess uric acid can form uric acid kidney stones. Not only that, but uric acid crystals can serve as a catalyst for the formation of kidney stones based on other substances such as calcium.
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Alternative Medicine for Gout
Posted by Victor Konshin in Alternative Medicine on April 15, 2009
Gout is the only disease in all of medicine that has been correctly identified as a unique disease throughout all of recorded medical history. For over four thousand years doctors and healers have recognized pain and swelling of the big toe as most likely being gout. People often ask me what the “scientific name” for gout is. It’s just ‘gout’ – there has never been any need to rename it. Things like heart attacks where given more specific names like, myocardial infarction, when our understanding increased, but there has never been any need to rename gout.
In the past, gout was a disease that doctors and healers obsessed over. The disease tended to affected mostly kings and noblemen because they had the means to live a lifestyle that made gout more prevalent - peasants rarely developed gout, even if they where genetically predisposed to gout because their sparse diet and over all fitness (from really hard work) cancelled out this predisposition.
This meant that anyone that came up with an effective treatment, or better yet, a cure for gout would be on the fast track to riches as the wealthy would be willing to pay handsomely for a solution to their gout pain. This resulted in a myriad of claims about gout treatments and cures, many of which not only still exist today but are widely believed as being helpful for gout. Of course, some of these ancient doctors actually did stumble on substances that have proven to be helpful for gout, but most just do not work.
In this article I will look at some of these treatments and look at which have scientific backing, which do not and which are potentially dangerous.
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New Gout Drugs – Coming Soon to a Pharmacy Near You
Posted by Victor Konshin in Gout Treatments, New Research on April 7, 2009
On valentine’s day this year, the FDA gave all of us gout sufferer’s a special valentine’s day gift. They approved the first new gout drug in more than forty years. But the good news doesn’t end there. There are several other new gout drugs that are in development.
Febuxostat
Febuxostat is the generic name for the drug released on Valentine’s day. It will be sold on the market under the brand name Ulroic® and is the first new xanthine oxidase inhibitor to be approved since allopurinol. Xanthine oxidase inhibitors are medications that block the xanthine oxidase enzyme from creating uric acid in the body and thus, lowers uric acid levels. This medication is chemically very different from allopurinol so it is hoped that people that have had allergic reactions to allopurinol will be able to take Uloric without any problems. Though there are many documented cases of people that where allergic to allopurinol that have taken febuxostat without any problems, I would still recommend caution if you have had severe reactions to allopurinol — better safe than sorry. Its best to start this medication at a very low dose and watch for any adverse reactions.
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